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Kratom naturally produces nitrogen-based chemicals called alkaloids that can have pronounced physiological actions on humans. The kratom plant has over 40 such naturally occurring bio-active alkaloids, of which perhaps the most well-known is mitragynine. Traditionally, day laborers in Southeast Asian countries chewed on kratom leaves to help with pain and energy. According to a 2020 survey of nearly 3,000 kratom users by John Hopkins Medicine, these days, a large portion of kratom users are using kratom to self-treat pain, while others use it for emotional or mental conditions.
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